Compare pentaxim and infanrix hexa. Vaccination accds. Komarovsky gives good advice about childhood vaccinations

May 11, 2014, 00:28

Infanrix is a vaccine for the prevention of diphtheria, tetanus, whooping cough. It has the following differences from the DTP vaccine: in the composition of the DTP vaccine, the pertussis component is represented by killed pertussis bacilli. In the composition of the Infanrix vaccine, the pertussis component is represented by parts of the cells of the pertussis bacillus. As a result of this difference in the composition of the pertussis component, the Infanrix vaccine is better tolerated by children and causes fewer reactions.
PENTAXIM is a combined vaccine for protection against 5 dangerous infections - pertussis, diphtheria, tetanus, poliomyelitis, Haemophilus influenzae type b (Hib).
This vaccine can be given to children from 3 months of age.
The effectiveness corresponds to that with the separate administration of vaccines, while the injection load on the child is sharply reduced
The acellular pertussis component (as in the Infnrix vaccine) significantly improves the tolerability of vaccination.
The polio component is represented by killed viruses, which eliminates the risk of such a rare but serious complication as vaccine-associated poliomyelitis.
Hemophilus influenzae (Hib infection) is a complex of diseases caused by the bacterium Haemophilus influenzae. The infection spreads with saliva - airborne and contact (through toys and other objects that children take in their mouths) ways. The most common forms of Hib infection are acute respiratory infections, including pneumonia and bronchitis, and meningitis.
Haemophilus influenzae occurs in 5-25% of people, but in kindergartens, the proportion of carriers can reach 40%, which causes frequent colds especially among children who are entering a nursery or kindergarten for the first time.
Unlike older children and adults, children under the age of 5, due to insufficient development immune system, cannot independently, without vaccination, form the necessary protection against hemophilic infection. In addition, the microbe capsule prevents the formation of long-term protection against this infection, therefore, children can carry a hemophilic infection repeatedly. Hemophilus influenzae affects all children under the age of 5 years.
Formula-feeding has been linked to an increased risk of Haemophilus influenzae meningitis and pneumonia because breast milk provides partial protection from hemophilic infection. The most common forms of hemophilic infection are diseases that occur as acute respiratory infections, pneumonia, bronchitis, and meningitis. The share of hemophilic pneumonia from the number of all pneumonias ranges from 5 to 20%. Often associated with meningitis and endocarditis
According to the Central Research Institute of Epidemiology, hemophilic infection is the cause of 35% to 50% of all purulent bacterial meningitis in children under 5 years of age. Purulent meningitis caused by Haemophilus influenzae is more severe and often gives neurological complications leading to disability of the child. however, its severity is higher. and the prognosis is worse. The frequency of complications after suffering hemophilic meningitis reaches 40%, and mortality is 10-30%.
Haemophilus influenzae is difficult to treat because Haemophilus influenzae is the most resistant to antibiotics. For this reason, even timely treatment with modern antibiotics often fails.
Russian studies have demonstrated a 4-10-fold decrease in the incidence of acute respiratory infections among children in children's preschool institutions after vaccination against Haemophilus influenzae.
Vaccination is the only way to prevent Haemophilus influenzae infection.
The Hib component of the Pentaxim vaccine provides high level protection against acute respiratory infections, meningitis, pneumonia, otitis media caused by this infection at a very early age.
The Pentaxim vaccine consists of 2 parts. Pertussis, diphtheria, tetanus, poliomyelitis component in one syringe. In another syringe Hib-component. Vaccination against whooping cough, diphtheria, tetanus, poliomyelitis is carried out 3 times. Hib-component is added to the syringe with pertussis, diphtheria, tetanus, poliomyelitis component, depending on the age of the child. If the child is under 6 months - three times. Child of the second half of the year - 2 times. A child older than a year - once.

DTP vaccination. Komarovsky E. O.- This is a well-known, very popular pediatrician who knows virtually everything about childhood diseases. He gives very helpful tips, which have already helped many young parents to avoid the early illnesses of their child. Today's article is devoted to the consideration advantages and disadvantages of DPT vaccination. Komarovsky also has his own opinion on this matter., and therefore at the end of the article you will see a video from this pediatrician.

What is the DTP vaccine (Komarovsky)? Video, description, consequences and indications.

Among the first childhood vaccinations (when the child reaches three months) is a vaccine against tetanus, whooping cough and diphtheria. It is certainly clear that these diseases are extremely difficult to tolerate, and are also very dangerous for the life of the baby, and therefore it is simply necessary to vaccinate against them. The most reactogenic vaccination is DPT. The reactogenicity of this vaccine is mainly due to the presence of a pertussis component (lipopolysaccharide or pertussis toxin).

This toxin provokes the occurrence of hemorrhage, leads to persistent vasoconstriction and degenerative changes in the kidneys, liver and spleen of the child. Under the influence of these substances, which are present in the DTP vaccine, mild, early reactions to the vaccine may occur. 95 percent of toxic reactions to vaccination develop in the first day. The child may experience lethargy, vomiting, sleep disturbance, and fever after DTP vaccination. Komarovsky advises parents in such a situation not to worry too much, since such symptoms will disappear on their own after about three days.

Which vaccination is better for a child: DTP or Infanrix? (Komarovsky).

There are two vaccines available on the current medical market for whooping cough, diphtheria and tetanus. The first, Russian, is DTP (in medical institutions it must be done free of charge), as well as a foreign analogue - Infanrix (French drug). Often, parents purchase the French vaccine on their own, in which case it must be stored at a certain temperature (in the refrigerator). If possible, you should agree and leave the drug in the pharmacy until the immediate moment of vaccination. Parents themselves must choose which vaccine the child needs, and therefore, it is first worthwhile to deal with the advantages and disadvantages of each.

heat treatment

DTP vaccination itself is a serious stress for a developing, fragile child's body. It is manifested by numerous side effects, such as swelling and redness at the injection site, decreased appetite, diarrhea, vomiting, nausea, lethargy, constant drowsiness, fever. It is generally accepted that Infanrix is much easier to tolerate by the child's body and causes fewer side effects. But the use of a foreign, French vaccine cannot absolutely protect the baby from possible complications. After any vaccination, it is recommended to give the child some kind of antihistamine medicine (against allergies) for several days.

Which vaccination is easier for a child to tolerate: DTP or Pentaxim? (Komarovsky).

Pentaxim is one of the new, acellular, that is, acellular vaccines that have replaced cellular (cellular) vaccines. Such vaccinations are less reactogenic, since they do not contain a bacterial, lipopopolysaccharide membrane, which causes complications after vaccination. It must be said that Pentaxim is also a highly immunogenic vaccine, that is, it gives a high immune response after vaccination, and protects against whooping cough, tetanus, diphtheria, hemophilic infection, polio and others.

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Hello, dear parents and everyone who is interested in the issues of vaccination of children!

Parents often come to my appointment with the question: “ What is the best vaccine Infanrix or Pentaxim?»

Today I will try to answer this question from the position of a practicing pediatrician.

Here are two drugs: Infanrix and Pentaxim.

Both drugs form high-quality reliable immune protection, are well tolerated, and have a high safety profile. Both drugs are imported and require the same storage conditions.

The Infanrix vaccine is a three-component vaccine, it consists of pertussis, diphtheria and tetanus components. In fact, this is an analogue of our domestic DTP vaccine. However, there is a fundamental difference between the domestic DTP and the Infanrix vaccine. In the domestic preparation, the pertussis component is represented by “fragments” of the cell wall of pertussis bacteria. In Infanrix, this component is highly purified acellular, i.e. acellular - presented on molecular level. This difference in vaccine structure, due to technical features production gives a fundamental difference in portability. Compared to domestic DTP, children vaccinated with the Infanrix vaccine are less likely to experience fever and other undesirable manifestations.

The Pentaxim vaccine is a five-component preparation, which also includes anti-pertussis, anti-diphtheria, anti-tetanus components, as well as components against poliomyelitis and against Haemophilus influenzae type B.

The anti-pertussis component in Pentaxim, as well as in Infanrix, is highly purified, cell-free - acellular.

Thus, the Pentaxim vaccine allows one-stage prevention of five infections at once.

In our country, the drug Infanrix-hexa has recently become available for use.

This drug was created on the basis of the Infanrix vaccine and has been used abroad for a long time. To date, tens of millions of doses of the vaccine have been introduced, the drug has proven its effectiveness and safety for children in practice.

Infanrix-hexa is a six-component drug that, in addition to the acellular pertussis component, components against diphtheria, tetanus, poliomyelitis, hemophilic infection, contains a component against hepatitis B.

Infanrix-hexa allows you to prevent SIX infections at once.

Thus, there is no unambiguous answer to the question: “Which is better: Infanrix or Pentaxim?”

Both Pentaxim and Infanrix and Infanrix-hexa are worthy drugs, similar in efficacy and safety.

The difference in composition, filling:

Infanrix - against three infections,

Pentakim - against five,

Infanrix-hexa against six infections.

All drugs are interchangeable - i.e. starting vaccination with one drug, you can continue to carry out prevention with others. The same possibility of substitution is also true for domestic DTP. In other words, having started to vaccinate DTP, further prevention can be carried out by any of these vaccines.

The difficulty of choosing a particular vaccine is not in answering the question - which is better, but in understanding which drug is more appropriate to use at each specific stage of the implementation of the vaccination calendar for this child.

Vaccination against several infections at once has huge benefits. One of them is to reduce the number of injections for a child! What is not less important!

I will tell you more about the concerns of parents, the advantages and disadvantages of multicomponent vaccines in the next video message.

Thanks for attention!

Having an impressive list side effects in many vaccines, it causes a terrible panic in parents: it is impossible not to be vaccinated, it is scary to do so. Vigilant mothers and fathers prefer imported sparing medicines to the domestic DTP vaccine. It makes no sense to talk about how much better or worse they are, because a lot depends on the condition of the child and the financial capabilities of the parents. Komarovsky is sure of one thing: it will not be easy to do without vaccinations, but which means to choose is a personal matter for everyone.

The drugs Infanrix Hexa and Pentaxim won the most popularity: which is better (Komarovsky recommends giving preference to a complex composition), depends on how the child reacts to the medications, and what vaccinations he has already been given.

Infanrix Hexa and Pentaxim have a similar effect and an impressive number of components: there are five of them in Pentaxim, and as many as six in Infanrix Hexa. But this does not mean that one of the compositions is better and the other is worse. It all depends on the child's need for specific components.

Infanrix Hexa and Pentaxim: pharmacological action

Both vaccines are designed to prevent the following diseases:

diphtheria,
hemophilia,
whooping cough and parawhooping cough,
poliomyelitis,
tetanus.

Infanrix Hexa additionally includes components that are the antigen of the hepatitis B virus. The drugs provide high protection against the diseases listed. The immune response comes quickly and has sufficient strength: the probability of contracting diseases against which prophylaxis is carried out is reduced to 5% or less, and the sick suffer the infection much more easily and recover without consequences in 98%.

Komarovsky evades answering what is better than Infanrix Hexa or Pentaxim - best option can only be suggested by the attending physician. Regardless of which drug is used, side effects both tools are about the same:

anxiety,
loss of appetite,
temperature rise,
allergic reactions,
swelling at the injection site.

The side effects usually go away within a day. If after 24 hours the child's condition worsens, you should immediately consult a doctor. Allergic reactions are the most dangerous, but they usually come on quickly. That is why doctors do not recommend leaving the clinic immediately after vaccination. If after half an hour the health of a small patient has not worsened, then the most terrible consequences of vaccination can not be afraid.

Komarovsky on what is better Infanrix Hexa or Pentaxim

Regardless of which remedy is chosen, Infanrix Hexa or Pentaxim, according to Komarovsky, it is better to use one drug at all stages of vaccination and revaccination. The vaccination schedule should be followed, according to which it is possible to determine not only the period of the procedures, but also the components of the vaccine. It is hard to say what is better for the child "Infanrix Hexa" or "Pentaxim", since a lot depends on the specific batch, which in itself can be better or worse.

Komarovsky recalls that when purchasing a vaccine, one should remember that it should be stored under certain conditions. Usually, the vaccine is kept at a low temperature: from 2 to 10 ° C, and the time spent by the composition outside the refrigerator should be minimal. The drug is usually taken from refrigerator compartment immediately before administration.

Komarovsky does not specifically say which drug is better, but notes that the number of complications after the introduction of Pentaxim is 2-2.5% lower. This is a small difference, given that the side effects after vaccination with a Belgian or French drug are much lower than after a domestic DPT.

When the baby reaches three months of age, parents have to face vaccination against 3 serious infections (tetanus, whooping cough and diphtheria). Immunization can be carried out with the Russian DTP drug, but it is poorly tolerated and often causes adverse reactions. Therefore, most parents tend to get vaccinated with foreign vaccines. However, which vaccine preparation to choose: Pentaxim or Infanrix?

Features of Infanrix

The vaccine preparation is a complete analogue of the Russian DTP vaccine. However, thanks to the use of 3 purified cell-free pertussis antigens, the vaccine is more easily tolerated. The active ingredients, along with the pertussis component of the vaccine, are diphtheria and tetanus toxoids.

Important! Infanrix refers to acellular vaccine preparations - products that have undergone thorough cleaning. Therefore, the vaccine is easier to tolerate, practically does not provoke the development of complications.

The following advantages of using Infanrix are distinguished:

The drug contains a cell-free pertussis component, so it is easily tolerated;
The price is almost 2 times lower compared to Pentaxim;
High efficiency;
Has a small number of contraindications.

The drug is produced in Belgium by the pharmaceutical concern GlaxoSmithKline. In the pharmacy network, you can find the drug Infanrix Hexa, which also protects the children's body from polio, hepatitis B and Hib infections. The vaccine is usually well tolerated, rarely leads to the development of severe adverse reactions. Its use allows several times to reduce the number of necessary injections as part of immunization.

However, during the application of the vaccine, it is necessary to take into account the vaccination schedule for hepatitis B. Primary immunization against this disease is carried out in the maternity hospital, the second vaccination is given at 2 months. In total, an infant needs 3 vaccinations. Therefore, when using the Infanrix Hexa vaccine, it is necessary to refuse to conduct a separate vaccination against hepatitis for a child.

Is it possible to revaccinate DPT with Infanrix vaccine?

These vaccines are analogues. Therefore, after 3 vaccinations, revaccination with Infanrix containing purified pertussis antigens is possible. In this case, it will be possible to minimize the risk of side effects, while the immune response will remain strong enough.

Is DPT revaccination possible after Infanrix?

If vaccination was carried out using Infanrix, then the first revaccination should be done with the same vaccine. The fact is that the vaccine preparation contains a purified acellular pertussis component, therefore, after the introduction of DTP, the development of pronounced side effects is possible. Therefore, doctors recommend using the same vaccine preparation for the entire course of immunization of the child.

Features of Pentaksim

The French vaccine preparation has a wide spectrum of action, therefore, it contributes to the development in the child's body of stable immunity against whooping cough, tetanus, hemophilic infection, 3 common and dangerous strains of polio. The vaccine is widely used for vaccination of children from 3 months. Each vaccine package contains a syringe and vial.

The syringe is filled with a vaccine that contains:

diphtheria toxoid;
2 pertussis antigens;
Inactivated polio virus particles type 1-3.

Separately, a lyophilisate is produced in a vial, which contains a polysaccharide of Haemophilus influenzae type b and tetanus toxoid. Before the introduction of the drug, the nurse mixes all the components of the vaccine. The vial and syringe contains the dose required to administer 1 child.

Advantages of the Pentaxim vaccine:

Contributes to the creation of a child's pronounced immune protection against 5 dangerous infections;
Ease of use and dosing - no need to do a lot of injections to the baby;
The drug rarely provokes the development of adverse reactions;
Virtually no contraindications;
May be used in children with disrupted immunization schedules.

Important! At its core, Pentaxim is an improved Infanrix. However, drugs differ not only in the set of antigens, but also in excipients. These differences can be significant if the child has an intolerance to any substances.

What is the best vaccine?

It can be difficult to choose which drug to use to vaccinate a baby: Infanrix or Pentaxim. Most parents want to reduce the number of injections an infant has to give to protect him from serious illnesses. If we compare vaccine preparations according to this principle, we can recommend the use of Pentaxim. Indeed, in the case of Infanrix, the child will additionally have to inject polio and Hib infections.

Important! Pentaxim contains killed polio virus particles, which can lead to an increase in the reactogenicity of the vaccine.

Infanrix contains 3 whooping cough antigens, therefore it provides a strong immune response, minimizing the risk of infection. Pentaxim was created on the basis of 2 antigens, therefore, in this aspect, it is slightly inferior to the Belgian vaccine.

But which vaccine preparation is better to use: Pentaxim or Infanrix? These vaccines are interchangeable and contain a cell-free component. But Pentaxim protects the child from 5 different infections, which is why many doctors recommend this vaccine preparation. However, before buying a vaccine, you need to consult a specialist, because he will be able to assess the child's health, advise the most optimal and safe vaccine preparation in each case.