Kagocel: instructions, price, reviews and analogues. Medicinal guide geotar Kagocel for the elderly

Antiviral and immunomodulatory drug.
Preparation: KAGOCEL®
The active substance of the drug: non appropriated
ATX encoding: J05AX
CFG: Antiviral and immunomodulatory drug. Interferon synthesis inducer
Registration number: Р №002027/01
Date of registration: 19.11.07
The owner of the reg. Award: NEARMEDIC PLUS OOO (Russia)

Kagocel release form, drug packaging and composition.

Tablets are round, biconvex, cream-colored, interspersed.

1 tab.
kagocel
12 mg

Excipients: potato starch, calcium stearate, ludipress (direct compression lactose with the composition: lactose monohydrate, povidone (kollidon 30), crospovidone (kollidon CL)).

10 pieces. - cellular contour packaging (1) - packs of cardboard.

The description of the drug is based on the officially approved instructions for use.

Pharmacological action of Kagocel

Antiviral and immunomodulatory drug. interferon synthesis inductor. The active substance is the sodium salt of the copolymer (1>4)-6-0-carboxymethyl-D-glucose, (1>4)-D-glucose and (21>24)-2,3,14,15,21,24 , 29,32-octahydroxy-23-(carboxymethoxymethyl)-7,10-dimethyl-4, 13-di(2-propyl)-19,22,26,30,31-pentaoxaheptacyclo dotriaconta-1,3,5(28 ),6,8(27), 9(18),10, 12(17), 13,15-decane.

It causes the formation in the body of the so-called late interferon, which is a mixture of alpha and beta interferons with high antiviral activity. Kagocel causes the production of interferon in almost all cell populations involved in the antiviral response of the body: T- and B-lymphocytes, macrophages, granulocytes, fibroblasts, endothelial cells. When one dose of Kagocel is taken orally, the interferon titer in the blood serum reaches its maximum values ​​after 48 hours. The dynamics of interferon accumulation in the intestine when the drug is taken orally does not coincide with the dynamics of titers of circulating interferon. In the blood serum, the content of interferon reaches high values ​​only 48 hours after taking Kagocel, while in the intestine the maximum production of interferon is noted already after 4 hours.

Kagocel, when prescribed in therapeutic doses, is non-toxic, does not accumulate in the body. The drug does not have mutagenic and teratogenic properties, is not carcinogenic and does not have an embryotoxic effect.

Pharmacokinetics of the drug.

Suction and distribution

When taken orally, about 20% of the administered dose of the drug enters the general circulation. After oral administration after 24 hours, it accumulates mainly in the liver, to a lesser extent - in the lungs, thymus, spleen, kidneys, and lymph nodes. Low concentration is observed in adipose tissue, heart, muscles, testicles, brain, blood plasma. The low content in the brain is due to the high molecular weight of the drug, which hinders its penetration through the BBB. In the blood plasma, the drug is found mainly in bound form: with lipids - 47%, with proteins - 37%. The unbound portion of the drug is about 16%. With repeated daily intake of the drug, Vd varies widely in all organs studied, the accumulation of the drug in the spleen and lymph nodes is especially pronounced.

breeding

It is excreted mainly through the intestines: 7 days after ingestion, 88% of the administered dose is excreted from the body, including 90% with feces and 10% with urine. The drug was not detected in exhaled air.

Indications for use:

Prevention and treatment of influenza and other acute respiratory viral infections in adults;

Treatment of influenza and other acute respiratory viral infections in children aged 6 years and older;

Treatment of herpes in adults.

Dosage and method of application of the drug.

Adults

For the treatment of influenza and SARS, it is prescribed in the first 2 days - 2 tab. 3 times / day, in the next 2 days - 1 tab. 3 times / day. In total, for a course lasting 4 days - 18 tab.

Prevention of acute respiratory viral infections is carried out in 7-day cycles: 2 days - 2 tab. 1 time / day, break for 5 days. Then the cycle is repeated. The duration of the prophylactic course varies from 1 week to several months.

For the treatment of herpes, 2 tablets are prescribed. 3 times / day for 5 days. In total, for a course lasting 5 days - 30 tab.

Children aged 6 and over

For the treatment of influenza and SARS, it is prescribed in the first 2 days - 1 tab. 3 times / day, in the next 2 days - 1 tab. 2 times/day In total, for a course lasting 4 days - 10 tab.

Side effects of Kagocel:

Possibly: allergic reactions.

Contraindications to the drug:

Pregnancy;

Children's age up to 6 years;

Increased individual sensitivity.

Use during pregnancy and lactation.

The drug is contraindicated for use during pregnancy.

Special instructions for the use of Kagocel.

The greatest efficiency in the treatment of Kagocel is achieved when it is prescribed no later than the 4th day from the onset of an acute infection. For prophylactic purposes, the drug can be used at any time, incl. and immediately after contact with the infectious agent.

Kagocel goes well with other antiviral drugs, immunomodulators and antibiotics.

Drug overdose:

Interaction of Kagocel with other drugs.

With the simultaneous use of Kagocel with other antiviral drugs, immunomodulators and antibiotics, an additive effect has been described.

Conditions of sale in pharmacies.

The drug is approved for use as a means of OTC.

Terms of storage conditions of the drug Kagocel.

The drug should be stored in a dry, dark place, out of the reach of children, at a temperature not exceeding 25°C. Shelf life - 2 years.

Active substance

Kagocel

Release form, composition and packaging

◊ Tablets from white with a brownish tint to light brown, round biconvex with brown patches.

Excipients: potato starch - 10 mg, calcium stearate - 0.65 mg, Ludipress (composition: lactose monohydrate - from 91% to 95%, (Kollidon 30) - from 3% to 4%, crospovidone (Kollidon CL) - from 3% up to 4%) - to obtain a tablet weighing 100 mg.

10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (3) - packs of cardboard.

pharmachologic effect

The active substance is the sodium salt of the copolymer of (1→4)-6-0-carboxymethyl-β-D-glucose, (1→4)-β-D-glucose and (21→24)-2,3,14,15 ,21,24,29,32-octahydroxy-23-(carboxymethoxymethyl)-7,10-dimethyl-4,13-di(2-propyl)-19,22,26,30,31-pentaoxaheptacyclo dotriaconta-1,3 ,5(28),6,8(27),9(18),10,12(17),13,15-decane.

It causes the formation in the human body of the so-called late ones, which are a mixture of alpha and beta interferons with high antiviral activity. Kagocel causes the production of interferons in almost all cell populations involved in the antiviral response of the body: T- and B-lymphocytes, macrophages, granulocytes, fibroblasts, endothelial cells. When one dose of Kagocel is taken orally, the titer of interferons in the blood serum reaches its maximum values ​​after 48 hours. The dynamics of accumulation of interferons in the intestine when taking the drug orally does not coincide with the dynamics of titers of circulating interferons. In the blood serum, the production of interferons reaches high values ​​only 48 hours after taking Kagocel, while in the intestine, the maximum production of interferons is noted already after 4 hours.

When administered in therapeutic doses, Kagocel is non-toxic and does not accumulate in the body. The drug does not have mutagenic and teratogenic properties, is not carcinogenic and does not have an embryotoxic effect.

The greatest efficiency in the treatment with Kagocel is achieved when it is administered no later than the 4th day from the onset of an acute infection. For prophylactic purposes, the drug can be used at any time, incl. and immediately after contact with the infectious agent.

Pharmacokinetics

Suction and distribution

When taken orally, about 20% of the administered dose of the drug enters the general circulation. 24 hours after administration, the drug accumulates mainly in the liver, to a lesser extent - in the lungs, thymus, spleen, kidneys, and lymph nodes. Low concentration is observed in adipose tissue, heart, muscles, testicles, brain, blood. The low content of kagocel in the brain is explained by the high molecular weight of the drug, which hinders its penetration through the BBB. In plasma, the drug is found predominantly in bound form: with lipids - 47%, with proteins - 37%. The unbound portion of the drug is about 16%.

With daily repeated administration of Kagocel, V d fluctuates widely in all organs studied. The accumulation of the drug in the spleen and lymph nodes is especially pronounced.

breeding

Excreted from the body mainly through the intestines: 7 days after ingestion, 88% of the administered dose is excreted from the body, incl. 90% - through the intestines and 10% - by the kidneys. The drug was not detected in exhaled air.

Indications

Contraindications

Dosage

The drug is taken orally, regardless of the meal.

Adults for treatment of influenza and SARS appoint in the first 2 days - 2 tab. 3 times / day, in the next 2 days - 1 tab. 3 times / day. In total, for a course lasting 4 days - 18 tab.

Prevention of influenza and SARS carried out in 7-day cycles: 2 days - 2 tab. 1 time / day, break for 5 days. Then the cycle is repeated. The duration of the prophylactic course is from 1 week to several months.

For treatment appoint 2 tab. 3 times / day for 5 days. Total for a course lasting 5 days - 30 tab.

Children aged 3 to 6 years for treatment of influenza and SARS appoint in the first 2 days - 1 tab. 2 times / day, in the next 2 days - 1 tab. 1 time / day In total, for a course lasting 4 days - 6 tab.

Children aged 6 years and over for treatment of influenza and SARS appoint in the first 2 days - 1 tab. 3 times / day, in the next 2 days - 1 tab. 2 times / day In total, for a course lasting 4 days - 10 tab.

At children aged 3 years and older flu and SARS prevention carried out in 7-day cycles: 2 days - 1 tab. 1 time / day, break for 5 days, then repeat the cycle. The duration of the prophylactic course is from 1 week to several months.

Side effects

Maybe: allergic reactions.

If any of these side effects get worse, or if the patient notices any other side effects, they should inform the doctor.

Overdose

Treatment: in case of accidental overdose, it is recommended to prescribe a plentiful drink, induce vomiting.

Some facts about the product:

Instructions for use

Price in the online pharmacy site: from 251

Some facts

SARS (acute respiratory viral diseases) affect the upper respiratory tract. Manifested by painful sensations in the throat, dizziness, weakness and profuse lacrimation. In the people, this condition is called a cold. It has similar symptoms to the flu, but develops more slowly. Lack of timely treatment causes severe cough, fever. Subsequently, complications such as sinusitis or otitis media may occur. There are many folk methods of treating colds, but dangerous consequences can only be prevented with the help of medications. The list of the most effective drugs also includes Kagocel. Its action is aimed at inducing the production of a special group of proteins (interferon). The active ingredient acts on all cells that have antiviral properties. Can be used for preventive purposes. The kit includes packaging and instructions for use.

Pharmacodynamics

Kagocel promotes the production of interferon gamma. It affects the protective function of several types of cells (macrophages, lymphocytes (T and B groups), fibroblasts, granulocytes, and endothelium). The maximum concentration of the substance is reached after 48 hours. The circulation of a special group of proteins persists for five days. The concentration of a substance in the intestine differs from the production of signaling molecules in the blood serum. In the digestive organ, the production of interferon was recorded already 3.5 hours after the use of the medication. To achieve quick results, you need to take the medication no later than the third day from the onset of symptoms of the disease. A medicine is also prescribed to prevent infection, including after contact with a likely source of infection.

Pharmacokinetics

The maximum concentration of the drug, 24 hours after the introduction into the body, was detected in the liver. The drug is also localized in the thymus, lungs, kidneys and spleen, but to a lesser extent. Low concentrations were recorded in the heart, testicles, brain, and blood plasma. The semi-permeable barrier between blood and nervous tissue makes it difficult for the drug to penetrate into the main organ of the central nervous system. With regular use of the drug in large doses, the volume of its distribution increases and is determined in all organs. The maximum concentration was found in the lymph nodes and spleen. Kagocel is excreted from the body after an average of 7 days. It leaves the body mainly with the help of the intestines (about 90% of the dose taken) and the kidneys (10%). Clinical trials have not confirmed the presence of traces of the drug in exhaled air.

Composition and form of release

Kagocel is produced in tablet form. The manufacturer uses cellular packaging made of polyvinyl chloride and aluminum foil, divided into 10 sections. Each tablet contains 12 mg of the active ingredient. The composition also includes additional ingredients such as potato starch, crospovidone, calcium stearate, povidone. Biconvex tablets may have a different color - from white to brown.

Indications for use

The drug is prescribed for children older than three years and adult patients for the treatment of acute respiratory viral infections and influenza. It is also suitable for eliminating the viral etiology of a herpes infection, but only in adults. Can be used in combination with other drugs to eliminate urogenital chlamydia. Kagocel is also indicated for prophylaxis during an influenza and SARS epidemic.

Side effects

Clinical cases of an acute negative reaction of the body to taking the drug have not been recorded. But Kagocel can cause allergic reactions in people with individual intolerance to one of the components of the drug. Before you start taking the medication, you need to get advice from a specialist.

Contraindications

The drug is easily tolerated by patients, but there is still a risk group. The drug is not prescribed during pregnancy and breastfeeding. It is forbidden to use an antiviral medication for children under the age of three, as well as for patients with lactose intolerance or lactase deficiency. May cause serious harm in glucose-galactose malabsorption.

Storage conditions

The packaging must be stored in a cool place, protected from direct sunlight. The air temperature should not exceed +25 degrees. Subject to all conditions, the drug can be used for four years from the date of release. The expiration date is printed on the packaging.

Use during pregnancy and lactation

Features of therapy

Kagocel is designed for internal use. The effectiveness of the drug is not related to food intake. Adult patients with the first symptoms of a viral infection or flu should take two tablets. The drug should be repeated three times a day. Then the amount of medication must be reduced. It is enough to take the medicine three times a day. Dosage - 1 tablet. Adult patients will need to take a course of 4 days. The maximum allowable rate is 18 tablets for the entire therapeutic period. As a prevention of infection with SARS or influenza, the drug is prescribed in cycles. During the first two days, you need to use two tablets at a time. After which there should be a break. After five days, the cycle should be repeated. The duration of admission depends on individual indicators. The decision must be made by the physician. It can be as little as seven days or it can take several months. Kagocel is also prescribed for herpes. Adults need to take the medicine three times a day. The optimal amount is 14 mg of the substance or 2 tablets at a time. Therapy should be 5 days. The maximum dosage for the entire period is 360 mg. The younger age category (children between the ages of three and six) can also take the medicine. The scheme of reception includes several stages. For the first two days, children are prescribed the drug twice a day, but only one tablet. Then the dosage is reduced. You can take the medication only once a day at a dosage of 12 mg. The total amount of interferon inductor for the entire period of therapy should not exceed 6 tablets. Children over six years of age for the treatment of viral diseases are prescribed medication for four days. The total dosage per course should not exceed 120 mg or ten tablets. During the first 48 hours, the patient should take one tablet three times a day. On subsequent days, the dosage is reduced to one tablet twice a day. It is possible to prevent infection in children older than three years with the help of preventive courses. The number of cycles is prescribed by the doctor. The standard prescription is one tablet per day. It is enough to take the drug for two days. Then you need to take a break, but not less than five days. Prevention can take a week or several months.

Alcohol compatibility

It is undesirable to take the medication simultaneously with alcoholic beverages. This combination can cause deviations in the functioning of the central nervous system. Ethanol has a great influence on endogenous type interferons. A dangerous combination of Kagocel and alcohol can lead to neurosis, depression, retinopathy and neuropathy. The drug continues to act on the body for an average of another week after ingestion. Only after 7 days you can drink drinks containing alcohol. It is important to remember that viral and infectious diseases have a strong effect on the body and can weaken the functioning of the kidneys, heart or liver.

Interaction with other drugs

The drug is prescribed in combination with immune system regulators, antibacterial and antiviral drugs.

Overdose

Cases of drug overdose have not been recorded, but a significant excess of the norm can cause vomiting, seizures in the umbilical zone, and dizziness. To eliminate these symptoms, you need to rinse the stomach and provide plenty of fluids.

Analogues

The following drugs have a similar effect in the treatment of viral diseases - Acigerpin, Atsik-oftal, Acyclostad, Acyclovir, Adapromin, Afludol, Adapromin, Afludol.

Terms of sale

The drug is sold in pharmacies without a prescription from the attending physician.

Kagocel is one of the most common and effective antiviral, immunomodulatory drugs. The tool is used to treat various colds, including influenza, as well as for preventive therapy during the period of maximum risk of infection.

Composition, packaging and release form

Kagocel is available in the form of rounded beige-brown tablets. The tablets are packaged in cell packs of 10 pcs. 1-3 blisters are placed in a cardboard pack along with annotation for use. The active ingredient of the drug is Kagocel. Each tablet contains 12 mg of this substance. Auxiliary components are:

• calcium stearate;
• potato starch;
• povidone;
• crospovidone;
• lactose monohydrate.

The number of additional components should be such that the total weight of the tablet is 100 mg. Each dragee is covered with a thin film shell, which dissolves only in the intestines. This protection helps prevent the breakdown of the active ingredient in the acidic environment of the stomach.

Mechanism of action

The therapeutic effect of Kagocel is based on the chemical properties of the active ingredient. It is produced by a multi-stage synthesis of a polyphenol obtained from cotton seeds, as well as carboxymethyl cellulose. The resulting substance settles as a sodium salt of organic origin.

The main component, due to its unique composition, specifically stimulates the body's production of its own proteins and late interferons. The drug works intensively, but it does not lead to the development of negative processes. Since side effects during treatment with Kagocel rarely occur, the drug is used in the treatment of childhood viral infections.

The principle of action of the drug is to develop interferon compounds after the first application. The process of strengthening the protective forces continues for the next 48 hours. The maximum amount of interferons accumulates in the intestine. The positive effect of the drug is recorded if the therapeutic course was started within the first 48-72 hours from the moment the first cold symptoms appeared.

Positive properties

The list of properties of Kagocel is wide. The drug affects the body as follows:

After application, the remains of the active ingredient accumulate in the liver, the rest (90%) is excreted through the gastrointestinal system and other fluids. Pathological accumulation of Kagocel in the body during medical studies was not revealed.

Indications for use

Positive results were noted both in the therapeutic and prophylactic course of taking Kagocel. Symptoms of a cold in the form of a runny nose, tearing disappear after 1-3 days from the start of therapy. It starts the production of its own immune cells that resist the effects of viruses. In addition to simple respiratory diseases, the drug is used for the following pathologies:

• viral infections (ARVI);
• influenza, including those accompanied by pronounced symptoms;
• herpes (acute form).

Among other things, the medicine helps to cope with other symptoms of colds: severe weakness, muscle pain, discomfort in the throat. Due to the complex effect of the drug, the patient feels relief already on the second day of treatment.

Contraindications and side effects

Despite the high efficiency of Kagocel, not all patients are allowed to use it. P Contraindications to course treatment are:

• personal intolerance to one or more components of the drug;
• excessive sensitivity to components;
• breastfeeding period;
• allergic reactions in history;
• lack of lactase production;
• children's age up to 3 years.

It is forbidden to take the drug to patients diagnosed with glucose-galactose malabsorption. With lactose intolerance, treatment with Kagocel is also not possible.

Pregnant women should not take the drug due to the lack of data on the effect of the drug on the fetus.

Side effects when taking the medication are rare and are expressed by allergic manifestations. If unpleasant symptoms appear in the form of a rash, edema, urticaria, you must immediately contact a medical institution.

Cases of overdose with Kagocel are not described. When taking an excessive number of tablets, it is necessary to induce vomiting and flush the stomach, and then take the patient to the hospital. Treatment in this case is symptomatic. There is no specific antidote.

Instructions for use

The maximum effectiveness of the therapeutic course of Kagocelom is achieved through strict adherence to the annotation. Tablets are taken orally, washed down with the necessary amount of liquid. Eating does not affect the effect of the drug.

The dosage of the drug depends on the age of the patient and the type of course therapy. To eliminate viruses, treat colds, adults are recommended to drink Kagocel three times a day, 2 tablets (24 mg). This pattern is followed for the first two days. For 3-4 days, a single dose of the drug is halved.

The duration of the treatment course does not exceed 4 days.

If the medicine is prescribed to adults as a prophylactic, then the regimen will be different. Course reception in this case is 7 days.

The first couple of days take two tablets once a day, then take a five-day break. Then the reception according to the scheme is repeated for two days. If necessary, the prophylactic cycle can be carried out 1-2 more times.

Childhood

For the treatment of viral infections, children are prescribed 1 tablet in the morning and evening for the first two days, and 1 tablet once a day for the next two days. Such a therapeutic scheme is shown to preschoolers 3-6 years old. In total, you need 6 tablets per course.

Older children and adolescents 7-13 years old in the first two days are required to give one tablet three times a day, then 1 tablet in the morning and evening. Only 10 tablets. Course treatment in both cases does not exceed 4 days.

Herpes treatment

Herpes is a complex infectious disease that is difficult to treat. Therapy of pathology is carried out in an intensive course. Patients are prescribed 2 tablets three times a day for 5 days. The general course is 30 tablets.

The maximum effect of therapy is achieved with an integrated approach. Treatment with Kagocel is combined with taking Acyclovir. After such a therapeutic course, recovery occurs within 5 days and relapses of the pathology are not recorded.

Kagocel for prevention

Prevention is the body's best defense against airborne viral diseases. During epidemics, doctors recommend taking the drug Kagocel.

Prevention in childhood

Antiviral tablets must be taken whole with plenty of water. Chew, dissolve, add the drug to tea or juice is not recommended. When preventing Kagocelom, it is necessary to strictly observe the dosage recommended by the manufacturer.

Children are allowed to take the drug after six years. Assign an antiviral agent in courses of 7 days. If necessary, the therapy cycle is repeated several times. In the first two days, the medicine is taken one tablet once a day, then 5 days pass. Depending on the severity of the epidemiological situation and the frequency of contacts with the infected, up to 10 preventive courses per year can be carried out.

Adult prevention

For the prevention of influenza and SARS in adults, the drug is also taken in courses of 7 days. In the first two days, two tablets per day are prescribed. It is desirable that the daily dose is taken at the same time. In the next 5 days, Kagocel is not taken. Observing the weekly cycles, it is possible to carry out prophylaxis for several months.

It is not recommended to take tablets with juice, tea and other liquids. So the absorption of the drug worsens. In this case, only pure water is needed. Also, remember to exceed the dosage. Specified in the instructions is strictly prohibited.

drug interaction

The compatibility of Kagocel with other drugs is quite good. Clinically significant interactions in the treatment simultaneously with other drugs have not been identified. With the combined use of the drug with antibiotics, immunomodulating agents, an additive effect occurs. That is, drugs enhance the effect of each other.

The effect of the drug on the management of mechanisms and vehicles has not been studied.

Simultaneous use of Kagocel with preparations containing ethanol, as well as alcoholic beverages, is prohibited. Stimulated synthesis of interferons under the influence of alcohol sometimes leads to the development of severe forms of retinopathy, neuropathy, to the occurrence of depressive syndromes caused by insomnia. Such changes in the body are irreversible.

Analogues and substitutes

The pharmaceutical industry today produces a huge amount of antiviral and immunomodulatory agents to help cope with colds and infectious diseases. There are no complete analogues of Kagocel in terms of composition and active ingredient. However, in return, pharmacy chains offer analogues with other active ingredients, but which have a powerful antiviral effect on the body.

Medicines come in a variety of forms, including suppositories, powders for solution, and tablets that need to be sucked. The following drugs are considered the most common antiviral immunomodulators:

Cheap analogues

All of these medicines today are often included in the treatment and prevention of colds, viral diseases. However, these drugs are quite expensive and not every patient can afford treatment with such expensive drugs. In addition to the listed drugs, pharmacy chains offer others that are no less effective, but the cost of which is much cheaper. Below is a list of such funds:

No. p / p	Name	Active substance	Manufacturer	How much does it cost in rubles
1	Remantadine	rimantadine	ROZPHARM CJSC (Russia)	70-100
2	Antigrippin, (granules for solution)	paracetamol + ascorbic acid + chlorvenamine maleate	Natur Product Pharma Sp. z o.o., Poland	100-130
3	Anaferon	antibodies to human gamma interferon		180-200
4	Viferon (candles)	human recombinant interferon alfa 2b	FERON LLC, Russia	230-250
5	Cycloferon	meglumine acridone acetate	OOO Scientific and Technological Pharmaceutical Firm POLYSAN, Russia	150-180
6	Arbidol	umifenovir	OJSC Pharmstandard-Leksredstva, Russia	200-250
7	Ergoferon	antibodies to human?-interferon + antibodies to histamine + antibodies to CD4	OOO NPF Materia Medica Holding, Russia	280-300

If you need to select a substitute for Kagocel, you need to contact a medical institution. The doctor will correlate the possible risks and effects of taking the drugs and build the correct treatment regimen.

Formula, chemical name: Kagocel is a copolymer of carboxymethyl cellulose and gossypol (1,6,7-trioxy-3-methyl-5-isopropyl-8-naphthaldehyde).
Pharmacological group: Immunotropic agents / immunomodulators / interferon inducers;
antiviral (with the exception of HIV) agents.
Pharmachologic effect: antiviral, immunomodulatory.

Pharmacological properties

Kagocel is able to induce the formation of interferon. Causes the production of late interferon, which is a mixture of beta and alpha interferons, which have strong antiviral activity. Kagocel leads to the formation of interferon in almost all cell populations that take part in the antiviral response of the body: macrophages, B- and T-lymphocytes, granulocytes, endothelial cells, fibroblasts. After ingestion of a single dose of the drug, the content of interferon in the blood becomes maximum after 2 days. The body's interferon response to Kagocel intake is characterized by long-term (up to 5 days) circulation of interferon in the blood. The dynamics of accumulation of interferon in the intestine after taking the drug does not coincide with that in the blood (in the blood, the content of interferon becomes maximum after 2 days, and in the intestine after 4 hours). The drug in therapeutic doses is non-toxic, does not accumulate in the body. Also, it does not have teratogenic, embryotoxic and mutagenic properties, it is not carcinogenic. The maximum efficiency in therapy with Kagocel is possible when taking it no later than the 4th day from the onset of the disease. For prevention, the drug can be used at any time, including immediately after contact with the source of infection. A day after taking kagocel, it accumulates mainly in the liver, to a lesser extent - in the thymus, lungs, spleen, lymph nodes, and kidneys. A small concentration is found in adipose tissue, muscles, heart, testicles, blood plasma, brain. In the blood, the absorbed drug circulates in the form associated with macromolecules: 37% - with proteins, 47% - with lipids, 16% circulates in an unbound form. 90% is excreted from the body mainly through the intestines, 10% through the kidneys.

Indications

Treatment and prevention of influenza and other acute respiratory viral infections in children (from 3 years old) and adults; treatment of herpes (in adults).

Dosing and Administration of Kagocel

Kagocel is taken orally, regardless of the meal. Adults: for the treatment of acute respiratory viral infections and influenza: the first 2 days, 24 mg 3 times a day, the next 2 days, 12 mg 3 times a day; for the prevention of influenza and SARS: 2 days 1 time per day, 24 mg, break for 5 days, repeat the cycle; for the treatment of herpes: 5 days 3 times a day, 24 mg. Children: for the treatment of acute respiratory viral infections and influenza from 3 to 6 years: the first 2 days 2 times a day, 12 mg, the next 2 days, 1 time a day, 12 mg; for the treatment of acute respiratory viral infections and influenza from 6 years: the first 2 days 3 times a day, 12 mg, the next 2 days 2 times a day, 12 mg; prevention of acute respiratory viral infections and influenza in children from 6 years: 2 days 1 time per day 12 mg, a break of 5 days, repeat the cycle. 12 mg = 1 tablet.
If you miss the next dose of Kagocel, take it as you remember, the next dose should be taken after the set time from the last use.
To achieve a therapeutic effect, the drug should be started no later than 4 days after the onset of the disease.

Contraindications for use

Hypersensitivity, age up to 3 years, pregnancy.

Application restrictions

No data.

Use during pregnancy and lactation

The use of Kagocel is contraindicated during pregnancy. During lactation while taking Kagocel, it is necessary to stop breastfeeding.

Side effects of Kagocel

Allergic reactions are possible.

Interaction of Kagocel with other substances

Kagocel is well combined with immunomodulators, antiviral drugs and antibiotics (an additive effect is observed).

Overdose

In case of accidental overdose of Kagocel, it is necessary to drink plenty of water, induce vomiting; if necessary, symptomatic therapy.